On the "home page" which lists currently active questions, the question titles are not aligned horizontally. (At least on SO and Meta.SO. I haven't checked other SE sites.)
When there's exactly one answer, the status on the left says "answer," which is slightly shorter than "answers" (plural) shown in all other cases. That difference in length causes the adjacent column's horizontal position to shift accordingly.
Admittedly, this imperfect alignment is very minor, but it's annoying when trying to scan down the currently active questions.
Repro'ed on current Chrome stable, on a couple machines, with various window sizes and display densities.
Update: Yes, browser zoom at 100%. Screenshot below.